Are the whitening effects of Glutathione permanent? Will my skin tone go back to its original colour once you stop taking it?

Its whitening effects are permanent only if you will maintain it (by avoiding exposure to sunlight).

The reason why are skin becomes white in using L-Glutathione is because it reverses the dark melanin pigments turning to a light pigments and reduces melanocytes which produces melanin. Less melanin,a whiter skin. L-Glutathione's whitening process starts inside the skin (dermal layer) going outside (epidermal layer), that's the reason why it takes time to be able to see initial change in your skin tone. The whitening process is goes head to foot meaning that you will have a white even skin tone in your whole body. Glutathione is the latest whitening innovation greatly recommended bydermatologists and skin care specialists. It is considered to be the most powerful, most versatile, and most important of the body's self-generated antioxidants.

Suggested duration for usage:

• If your skin is medium brown: take it for at least one to three months


• If your skin is dark brown: take glutathione for at least three to six months


• If your skin is dark: take it for six to 12 months


• If your skin is very dark: may need L glutathione for at least two years or even more


• Once a person has her desired skin colour: the maintenance dose can be 1 tab of 500mg-100mg once a day

It is advisable to still continue taking the pills even though you have achieved the skin tone you want. Take 1 capsule a day as maintenance. We all know that L-Glutathione is very good to our health and so taking it in long term will not only make us white but also it will promote better health.

Are the whitening effects of Glutathione permanent?

In taking care and maintaining something in our body, you must have a healthy habit and discipline to stay with the ideal effects that we want. Therefore, we must take 1 capsule a day for our maintenance and we should not expose ourselves from the harmful rays of sun.

Even though the sunlight was said that it provides vitamin D, everyone is aware of the depletion of the ozone layer, and anything that is over wouldn't have a better result in the body. In fact too much exposure will increases the melanin pigments in the skin, thus, might delay the whitening process. It's not really bad to be exposed to sunlight as long as we have protection such as sun block. Use sunblock or sunscreen lotion that has an SPF of 30-60. It will protect you from the harmful effects of the sun.

High dosage of Glutathione: Glutathione is water-soluble, meaning that if there would be an excessive amount of intake it would still be excreted through urine.

Unlike any other whitening pills / capsules, glutathione don't just concentrate on whitening of the skin itself, it is also an anti oxidant and anti aging pill which makes us healthy and stress free. No harmful effects on the body and is recommended by eminent dermatologist and doctors for people with liver problems.

HoWs Glut Works to Glow Your SKIN

This is the inner layer of the skin called Dermis and the outer surface which is visible in our eyes is the Epidermis. The primary determinant of variability in human skin color is the Melanin and Melanocyte is a cell that synthesizes it. L-glutathione,, starts the lightening process in the Dermis working its way out to the surface.

This is the point where the metabolic pathway of Melanin begins. As you see in the diagram GSH(Reduced Glutathione) intervenes the metabolism. There are certain kinds of compounds that inhibits the Tyrosinase Activity and L-glutathione is one of them.

The oral use of Reduced Glutathione(L-glutathione) inhibits the Tyrosinase Activity. Once it has been inhibited, the metabolic pathway then reverses its course going to the synthesis of light pigmented melanin called Phaeomelanin instead of synthesizing dark pigmented melanin called Eumelanin. The cycle continously flow as long as the presence of L-glutathione co-exist in the metabolic pathway of melanin. Finally, light skin will reveal to the surface gradually changing your complexion.

Mechanism of action

Glutathione is an extremely important cell protectant. It directly quenches reactive hydroxyl free radicals, other oxygen-centered free radicals, and radical centers on DNA and other biomolecules. Glutathione is a primary protectant of skin, lens, cornea, and retina against radiation damage and other biochemical foundations of P450 detoxification in the liver, kidneys, lungs, intestinal, epithelia and other organs.

Glutathione is the essential cofactor for many enzymes that require thiol-reducing equivalents, and helps keep redox-sensitive active sites on enzyme in the necessary reduced state. Higher-order thiol cell systems, the metallothioneins, thioredoxins and other redox regulator proteins are ultimately regulated by Glutathione levels—and the GSH/GSSG redox ratio. GSH/GSSG balance is crucial to homeostasis—stabilizing the cellular biomolecular spectrum, and facilitating cellular performance and survival.

Glutathione and its metabolites also interface with energetics and neurotransmitter syntheses through several prominent metabolic pathways. Glutathione availability down-regulates the pro-inflammatory potential of leukotrienes and other eicosanoids. Recently discovered S-nitroso metabolites, generated in vivo from Glutathione and NO (nitric oxide), further diversify Glutathione's impact on metabolism.

Monograph provided by Alternative Medicine Review (www.thorne.com)

Glutathione Used in Various Disease States:

• Acetaminophen Toxicity • ALS • Alzheimer’s • ASD (Autism Spectrum Disorder) • Cancer • Chronic Fatigue

• COPD • Cystic Fibrosis • Diabetes • Heavy Metal Toxicity • HIV

• Huntington’s Disease • Lyme Disease • Multiple Sclerosis • Parkinsons Disease • Stroke

Essential GSH™:

Essential GSH™ is a breakthrough liquid formulation uniquely designed to increase the systemic bioavailability of Glutathione, via a liposomal-based delivery. It provides Glutathione in a convenient, absorbable form that your body can rapidly use using pharmaceutical grade liposomes. Because liposomes are made from the same material that your cell membranes are made from, it fuses with cell membranes and allows for absorption of Glutathione into the cells.

Biochemistry and Metabolism:

Biochemistry and Metabolism:

Reduced Glutathione (GSH) is a linear tripeptide of L-glutamine, L-cysteine, and glycine. Technically N-L-gamma-glutamyl-cysteinyl glycine or L-Glutathione, the molecule has a sulfhydryl (SH) group on the cysteinyl portion, which accounts for its strong electron-donating character.

As electrons are lost, the molecule becomes oxidized, and two such molecules become linked (dimerized) by a disulfide bridge to form Glutathione disulfide or oxidized Glutathione (GSSG). This linkage is reversible upon re-reduction.

Glutathione is under tight homeostatic control both intracellularly and extracellularly. A dynamic balance is maintained between GSH synthesis, it’s recycling from GSSG/oxidized Glutathione, and its utilization.

Glutathione synthesis involves two closely linked, enzymatically-controlled reactions that utilize ATP. First, cysteine and glutamate are combined by gamma-glutamyl cysteinyl synthetase. Second, GSH synthetase combines gamma-glutamylcysteine with glycine to generate Glutathione. As Glutathione levels rise, they self-limit further GSH synthesis; otherwise, cysteine availability is usually rate-limiting. Fasting, protein-energy malnutrition, or other dietary amino acid deficiencies limit Glutathione synthesis.

Glutathione recycling is catalyzed by Glutathione disulfide reductase, which uses reducing equivalents from NADPH to reconvert GSSG to 2GSH. The reducing power of ascorbate helps conserve systemic Glutathione.

Glutathione is used as a cofactor by (1) multiple peroxidase enzymes, to detoxify peroxides generated from oxygen radical attack on biological molecules; (2) transhydrogenases, to reduce oxidized centers on DNA, proteins, and other biomolecules; and (3) Glutathione S-transferases (GST) to conjugate Gluathione with endogenous substances (e.g., estrogens), exogenous electrophiles (e.g., arene oxides, unsaturated carbonyls, organic halides), and diverse xenobiotics. Low GST activity may increase risk for disease—but paradoxically, some Glutathione conjugates can also be toxic.

Direct attack by free radicals and other oxidative agents can also deplete Glutathione. The homeostatic Glutathione redox cycle attempts to keep Glutathione repleted as it is being consumed. Amounts available from foods are limited (less that 150 mg/day), and oxidative depletion can outpace synthesis.

The liver is the largest Glutathione reservoir. The parenchymal cells synthesize GSH for P450 conjugation and numerous other metabolic requirements—then export GSH as a systemic source of SH-reducing power. Glutathione is carried in the bile to the intestinal luminal compartment. Epithelial tissues of the kidney tubules, intestinal lining and lung have substantial P450 activity—and modest capacity to export Glutathione.

Glutathione equivalents circulate in the blood predominantly as cystine, the oxidized and more stable form of cysteine. Cells import cystine from the blood, reconvert it to cysteine (likely using ascorbate as cofactor), and from it synthesize GSH. Conversely, inside the cell, Glutathione helps re-reduce oxidized forms of other antioxidants—such as ascorbate and alpha-tocopherol.

what is GLUTATHIONE

Glutathione: The Super Supplement of the Decade Who wouldn’t like to have a naturally occurring substance that acts as a super antioxidant, an immune system booster, and a detoxifier? As a bonus, it will help your body repair damages caused by stress, pollution, radiation, infection, drugs, poor diet, aging, injury, trauma, and burns? An army of advanced researchers are saying that glutathione can do all the above and maybe more. But can you believe such sweeping claims? What is the evidence to back them up? Here is what the experts have to say: What is Glutathione? Glutathione is a super antioxidant that is important for your good health because they neutralize “free radicals”, which can build up in cells and cause damage. Because glutathione exists within the cells, it is in a prime position to neutralize “free radicals”. It also has potentially widespread health benefits because it can be found in all types of cells, including the cells of the immune system, whose job is to fight disease. What Does Glutathione Specialist do? The strong antioxidant effect of glutathione helps keep cells running smoothly. Glutathione expert, Jeremy Appleton, ND, Chairman of the Department of Nutrition at the National College of Naturopathic Medicine, say it also helps the liver remove chemicals that are foreign to the body, such as drugs and pollutants. “IF you look in a hospital situation at people who have cancer, AIDS, or other very serious disease, almost invariably they are depleted of glutathione,” says Dr. Appleton. “The reasons for this are not completely understood, but we do know that glutathione is extremely important for maintaining intracellular health.”

How should Glutathione be Taken?
Glutathione is not absorbed into the body when taken by mouth. One way to get around that is to take it by injection in the vein. Another way is to take amino acids precursors, that is, the molecules the body needs to make glutathione, but there is no solid proof this works and most doctors doubt its validity.

Glutathione Specialist is a New major breakthrough because it uses the latest technology of micro-encapsulating reduced glutathione, methylcobolamine B12, Folinic acid into phosphatidylcholine, an essential phospholipids that is natural to the cell and brain, called Glutathione Lyposome to deliver directly into the blood stream, even crossing the Brain Barrier in very high concentrations effectively and quickly.

Dr. Appleton says “Glutathione and other antioxidants, far from interfering with the activity of chemotherapy, appear to reduce side effects without decreasing efficacy and may, in fact, improve the efficacy of the chemotherapy in fighting cancer.”

Glutathione is also used to prevent oxidative stress in most cells and helps to trap and neutralize “free radicals” that can damage DNA and RNA. There is a direct correlation with the speed of aging and the reduction of glutathione concentrations in intracellular fluids. As individuals grow older, glutathione levels drop, and the ability to detoxify free radicals decreases.

Glutathione preliminary evidence that it might eventually prove to be useful in the management of some cancers, atherosclerosis, diabetes, lung disorders, noise-induced hearing loss, male infertility and to help prevent various heavy metal and chemical toxicities. Glutathione also has been researched for AIDS associated Cachexia, Cystic Fibrosis, Parkinsons, ADHD, Autism, Multiple Sclerosis, Cancer, Mercury poisoning, Lupus, ALS, and liver diseases.

A case history by Mr. Martin, a semi-retired researcher, experienced hands-on evidence of the power of raising his Glutathione level. For years, he suffered from Chronic Fatigue Syndrome and fibromyalgia that countless medical practitioners were not able to neither recognize nor treat. When he became so debilitated that he considered purchasing a walker or a wheel chair by his early 50s, he decided to take charge of his own health. After doing extensive research, then boosting his glutathione levels, he regained his mobility and natural high energy. "Within a week, I realized I didn't hurt anymore," says Mr. Martin. "I just got better and better. It was so simple and so astounding." He has never looked back. Today, he continues to maintain his glutathione level, which is vibrant and healthy, and he "rarely gets a cold."

Increased Glutathione levels have been researched in:
1. Detoxify the liver
2. Improve Lung Function
3. Improve Heart Function
4. Increased Energy, Endurance, and Stamina
5. Protect the Skin from UV sunlight
6. Strengthen Immune Function
7. Helping AIDS related symptoms
8. Multiple Sclerosis, Lupus, ALS.
9. ADHD & Autism
10. Cancer & Chemotherapy side effects
11. Alzheimer, Parkinson, and Memory Deficits
12. Diabetes & Sugar Metabolism
13. Cardio Vascular Disease & Athrosclerosis
14. Adrenal Fatigue & Fibromyalgia

Directions:
• Take ¼ of a bottle once or twice daily with water or juice on empty stomach or as directed by your professional health care provider.
• Refrigerate after opening.